COX-2 drugs work similarly to popular anti-inflammatory pain relievers like naproxen and ibuprofen. Although the makers of COX-2 drugs have not advertised these types of drugs as being more effective than naproxen or ibuprofen, the drugs do carry a lower risk of stomach and intestinal side effects.

The Benefits

COX-2 drugs help to relieve pain and inflammation in patients suffering from multiple sclerosis, or MS. As the disease progresses in patients with MS, they may experience pain or inflammation in certain areas of their bodies. While COX-2 drugs are part of a group of medications called non-steroidal anti-inflammatory drugs that are most popularly prescribed for arthritis patients, they can also be beneficial to patients living with MS. These drugs are particularly beneficial to patients with a tendency toward intestinal problems or stomach bleeding. The COX-2 drugs may be less irritating and toxic to the stomach and gastro-intestinal lining than the other anti-inflammatory drugs such as naproxen and ibuprofen.

Precautions

While these drugs do hold benefits for people living with MS, they should be taken with caution just as other prescription drugs are. There is evidence that these drugs increase the risk of heart problems in patients 65 and over. Examples of these drugs include Bextra and Celebrex. However, the concern for heart problems also extends to anyone with a history of heart problems or anyone who carries an underlying risk of heart disease or stroke. In these patients, COX-2 drugs should be used with caution.

Patients who have a history of edema, or fluid retention, and high blood pressure should be monitored, as well. The COX-2 drugs may make high blood pressure and fluid retention worse. Also, patients with a history of kidney problems should take these drugs with caution as they may carry a risk for kidney problems, as do many anti-inflammatory drugs.

One piece of good news concerning the side effects associated with COX-2 drugs is that the risk of heart disease and stroke does not continue after patients have stopped taking the drugs. Studies have shown no adverse effects on the hearts of patients once they discontinue use of the medications. However, it is still a good idea for patients to maintain regular visits with their doctor for monitoring of any future concerns.